Oncogenic kinase fusions and signaling
Tulpule A*, Guan J*, Neel D*, Allegakoan H, Lin YP, Brown D, Chou YT, Heslin A, Chatterjee N, Perati S, Menon S, Nguyen TA, Debnath J, Ramirez AD, Shi X, Yang B, Feng S, Makhias S, Huang B#, Bivona TG#. Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules. Cell. 2021. PMID: 33848463. Commentary in Molecular Cell (PMID: 34143968) by Matt Cuneo and Tanja Mittag.
Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, et al. RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Nature Medicine 2015 Sep; 21(9):1038-1047
Tulpule A and T. G. Bivona (2020). "Acquired Resistance in Lung Cancer." Annual Review of Cancer Biology 4(1): 279-297.
DNA repair and pediatric cancer
Menon S, Allegakoan H, Breese M, Lin YP, Heslin A, Horlbeck M, Flannagan J, Weissman J, Sweet-Cordero A, Bivona TG#, Tulpule A#. Ewing sarcoma tumors are defective in ***-dependent DNA damage responses (Planned submission September 2022).
Lavergne, V., A. Sabnis, A. Tulpule, P. R. Davidson, C. Kline, K. Matthay, T. Nicolaides, R. Goldsby, S. Braunstein, S. E. Fogh, P. K. Sneed, P. Menzel, A. Nakamura, S. G. DuBois, D. A. Haas-Kogan and J. L. Nakamura (2020). "Germline MUTYH Mutation in a Pediatric Cancer Survivor Developing a Secondary Malignancy." Journal of Pediatric Hematology Oncology 42(7): e647-e654.
Oral Presentations:
UCSF Cancer Center Seminar, January 2022.
American Association for Cancer Research (AACR) Annual Meeting (2021), Pediatric Cancer Working Group (PCWG) Town Hall highlighting Young Investigators.
A CRISPRi Screen Identifies Pathways That Promote Sensitivity to Cytotoxic Chemotherapy in Ewing’s Sarcoma. Connective Tissue Oncology Society Annual Meeting, Salt Lake City.
Pediatric Marrow Failure and Stem Cells
Tulpule A, Kelley JM, Lensch MW, McPherson J, Park IH, Hartung O, et al. Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction. Cell Stem Cell 2013 Jun 6; 12(6):727-736.
Tulpule A, Lensch MW, Miller JD, Austin K, D'Andrea A, Schlaeger TM, et al. Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage. Blood 2010 Apr 29; 115(17):3453-3462. Cover artwork.
Tulpule A, Daley GQ. Efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi. Methods Molecular Biology 2009; 482:35-42.
Kelley JM, Tulpule A, Daley GQ. Proteolytic autodigestion: common tissue pathology in Shwachman-Diamond syndrome? Cell Cycle 2013; 12(22):3457-3458.
Austin KM, Gupta ML,Jr, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, et al. Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. Journal of Clinical Investigation 2008 Apr; 118(4):1511-1518.