EWS in DNA repair and cancer

Tulpule A, Heslin A, Lin H, Horlbeck M, Flannagan J, Weissman J, Bivona TG. Homologous recombination dependence defines EWS fusions and *** mutant cancers. (Planned submission July 2018)

Oral Presentations:

UCSF Friday Cancer Center Seminar, March 2018

A CRISPRi Screen Identifies Pathways That Promote Sensitivity to Cytotoxic Chemotherapy in Ewing’s Sarcoma. Connective Tissue Oncology Society Annual Meeting, Salt Lake City.


Oncogenic kinase fusions and signaling

Tulpule A*, Guan J*, Neel D*, Heslin A, Lin H, Olivas V, Huang B**, Bivona TG**. EML4-ALK protein clusters activate RAS-MAPK pathway via ***. Planned submission June 2018.

Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, et al. RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Nature Medicine 2015 Sep; 21(9):1038-1047


Pediatric Marrow Failure, DNA repair and Stem Cells

Tulpule A, Kelley JM, Lensch MW, McPherson J, Park IH, Hartung O, et al. Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction. Cell Stem Cell 2013 Jun 6; 12(6):727-736.

Tulpule A, Lensch MW, Miller JD, Austin K, D'Andrea A, Schlaeger TM, et al. Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage. Blood 2010 Apr 29; 115(17):3453-3462. Cover artwork.

Tulpule A, Daley GQ. Efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi. Methods Molecular Biology 2009; 482:35-42.

Kelley JM, Tulpule A, Daley GQ. Proteolytic autodigestion: common tissue pathology in Shwachman-Diamond syndrome? Cell Cycle 2013; 12(22):3457-3458.

Austin KM, Gupta ML,Jr, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, et al. Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. Journal of Clinical Investigation 2008 Apr; 118(4):1511-1518.