Oncogenic kinase fusions and signaling

Tulpule A*, Guan J*, Neel D*, Allegakoan H, Lin YP, Brown D, Chou YT, Heslin A, Chatterjee N, Perati S, Menon S, Nguyen TA, Debnath J, Ramirez AD, Shi X, Yang B, Feng S, Makhias S, Huang B#, Bivona TG#. Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules. Cell. 2021 Apr 8. Epub ahead of print. PMID: 33848463

Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, et al. RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Nature Medicine 2015 Sep; 21(9):1038-1047

Tulpule A and T. G. Bivona (2020). "Acquired Resistance in Lung Cancer." Annual Review of Cancer Biology 4(1): 279-297.


EWS in DNA repair and cancer

Menon S, Allegakoan H, Breese M, Lin YP, Heslin A, Horlbeck M, Flannagan J, Weissman J, Sweet-Cordero A, Bivona TG#, Tulpule A#. Ewing sarcoma tumors display defective ***-dependent DNA damage responses (Planned submission July 2021).

Oral Presentations:

UCSF Friday Cancer Center Seminar, March 2018

A CRISPRi Screen Identifies Pathways That Promote Sensitivity to Cytotoxic Chemotherapy in Ewing’s Sarcoma. Connective Tissue Oncology Society Annual Meeting, Salt Lake City.


Pediatric Marrow Failure, DNA repair and Stem Cells

Tulpule A, Kelley JM, Lensch MW, McPherson J, Park IH, Hartung O, et al. Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction. Cell Stem Cell 2013 Jun 6; 12(6):727-736.

Tulpule A, Lensch MW, Miller JD, Austin K, D'Andrea A, Schlaeger TM, et al. Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage. Blood 2010 Apr 29; 115(17):3453-3462. Cover artwork.

Tulpule A, Daley GQ. Efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi. Methods Molecular Biology 2009; 482:35-42.

Kelley JM, Tulpule A, Daley GQ. Proteolytic autodigestion: common tissue pathology in Shwachman-Diamond syndrome? Cell Cycle 2013; 12(22):3457-3458.

Austin KM, Gupta ML,Jr, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, et al. Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. Journal of Clinical Investigation 2008 Apr; 118(4):1511-1518.